Pureza em pó branco Sarrms AICAR para queima de gordura

Descrição
(1). It is an intermediate contained in the generation of inosine monophosphate.It primarily functions as an AMP-activ-ated pro-tein-kin-ase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production.

(2). Ai-c-ar is an adenosine analog that selectively activates AMP-acti-vat-ed pr-ot-ein ki-na-se (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

(3). Ai-c-ar can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion.

(4). With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion.Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

Função
Ai-c-ar (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that Ai-c-ar blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that Ai-c-ar can mimic the activity of in-su-lin (sc-211647) by activating AMPK (AM-P-activ-at-ed pr-ot-ein k-in-ase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). Ai-c-ar is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
AMP-ac-tiv-a-ted pro-te-in kin-a-se ( AMPK ) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.Ai-c-ar is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.Ai-c-ar (0.5 mM) inhibits in-su-lin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.